Research Links Two Possible Genetic Variations to Age-Related Hearing Loss Scientists have discovered two genome variants that may contribute to age-related hearing loss. A variation near the ISG20 gene, and a second variant within TRIOBP, a gene previously associated with another type of hearing loss, were singled out in research from the University of California, San Francisco, and Kaiser Permanente ... Research in Brief
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Research in Brief  |   February 01, 2017
Research Links Two Possible Genetic Variations to Age-Related Hearing Loss
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Hearing Disorders / Special Populations / Genetic & Congenital Disorders / Research in Brief
Research in Brief   |   February 01, 2017
Research Links Two Possible Genetic Variations to Age-Related Hearing Loss
The ASHA Leader, February 2017, Vol. 22, 16. doi:10.1044/leader.RIB3.22022017.16
The ASHA Leader, February 2017, Vol. 22, 16. doi:10.1044/leader.RIB3.22022017.16
Scientists have discovered two genome variants that may contribute to age-related hearing loss. A variation near the ISG20 gene, and a second variant within TRIOBP, a gene previously associated with another type of hearing loss, were singled out in research from the University of California, San Francisco, and Kaiser Permanente Northern California.
Led by Thomas Hoffmann, UC San Francisco professor of epidemiology and biostatistics and member of the university’s Institute for Human Genetics, researchers performed a genome-wide association study of white participants—with 6,527 age-related hearing impairment cases and 45,882 controls—from the Genetic Epidemiology Research on Adult Health and Aging cohort. They were able to replicate their results in other cohorts, including Latino, East Asian and African-American.
The study, published in the journal PLOS Genetics, provides evidence that “age-related hearing loss may share a common biological basis with other forms of hearing impairment,” says Hoffman.
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February 2017
Volume 22, Issue 2