From the Journals: Researchers Find Gene That Nearly Triples Risk of Alzheimer's An international team including researchers from Mayo Clinic has identified a gene so powerful it nearly triples the risk of Alzheimer's disease. It is the most potent genetic risk factor for Alzheimer's identified in the past ... From the Journals
From the Journals  |   January 01, 2013
From the Journals: Researchers Find Gene That Nearly Triples Risk of Alzheimer's
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Special Populations / Genetic & Congenital Disorders / Older Adults & Aging / From the Journals
From the Journals   |   January 01, 2013
From the Journals: Researchers Find Gene That Nearly Triples Risk of Alzheimer's
The ASHA Leader, January 2013, Vol. 18, 32. doi:10.1044/leader.FTJ5.18012013.32
The ASHA Leader, January 2013, Vol. 18, 32. doi:10.1044/leader.FTJ5.18012013.32
An international team including researchers from Mayo Clinic has identified a gene so powerful it nearly triples the risk of Alzheimer's disease. It is the most potent genetic risk factor for Alzheimer's identified in the past 20 years, according to a study in the New England Journal of Medicine (November 2012).
Using new sequencing techniques to home in on the TREM2 gene, researchers then conducted additional TREM2 sequencing. These studies led to identification of a set of rare variants in TREM2 that occurred more often in 1,092 Alzheimer's disease patients than in a control group of 1,107 healthy people. 
Then researchers evaluated the most common variant, R47H, in follow-up studies of a large number of people with Alzheimer's disease and controls. They genotyped and analyzed R47H in DNA samples from 1,994 people with Alzheimer's disease and 4,062 "control" participants—individuals verified not to have Alzheimer's. 
Evaluation of the patients and control participants in follow-up studies showed unequivocally that the R47H variant of TREM2 substantially increases the risk of Alzheimer's disease. Search doi: 10.1056/NEJMoa1211851.
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January 2013
Volume 18, Issue 1